ABSTRACT
RESUMEN La hiperqueratosis es un trastorno caracterizado por el engrosamiento de la capa externa de la piel, que está compuesta de queratina, una fuerte proteína protectora. Puede ser causada por fricción, conllevando la aparición de callosidades, inflamación crónica, eccema o trastornos genéticos, como la ictiosis ligada al cromosoma X. Se presentó el caso de un paciente de 47 años, que acudió al Servicio de Ortopedia por lesión escamosa a nivel de ambas regiones plantares con dificultad para la marcha. El tratamiento quirúrgico fue el empleado en este paciente para la obtención de la biopsia exerética. La evolución fue favorable en el postoperatorio mediato e inmediato, y el paciente se incorporó de forma rápida a su vida normal. Con este caso se identificaron las características clínicas de la hiperqueratosis plantar, así como el uso de la biopsia exerética como estándar de oro para el diagnóstico positivo en los tumores periféricos. Un diagnóstico adecuado por el médico inicial, la interrelación del Servicio de Ortopedia con la consulta de tumores periféricos, y el tratamiento quirúrgico seleccionado, constituyen factores determinantes en la evolución favorable de los pacientes con este diagnóstico (AU).
ABSTRACT Hyperkeratosis is a disorder characterized by thickening of the outer layer of the skin, which is composed of keratin, a strong protective protein. It can be caused by friction, leading to callosities, chronic inflammation, eczema or genetic disorders such as X chromosome-linked ichthyosis. We presented the case of a patient, aged 47 years, who attended the Orthopedic Service for scaly lesion at the level of both plantar regions with difficulties to walk. Surgical treatment was used in this patient to obtain an exeretic biopsy. The evolution was favorable in both the mediate and immediate postoperative period, and the patient quickly returned to his normal life. This case identified the clinical characteristics of plantar hyperkeratosis and the use of exeretic biopsy as a gold standard for positive diagnosis in the peripheral tumors. An adequate diagnosis by the initial physician, the interrelation of the orthopedic service with the consultation of peripheral tumors, and the chosen surgical treatment are determining factors in the favorable evolution of patients with this diagnosis (AU).
Subject(s)
Humans , Female , Peripheral Nervous System Neoplasms/diagnosis , Keratoderma, Palmoplantar/diagnosis , Orthopedics/methods , Skin Diseases , Biopsy/methods , Keratoderma, Palmoplantar/surgery , Keratoderma, Palmoplantar/genetics , Keratoderma, Palmoplantar/epidemiologyABSTRACT
Mal de Meleda is a recessive transgressive palmoplantar keratoderma. We report the epidemiological, clinical and progressiveness aspects of the disease in 16 patients of a large consanguineous Tunisian family, the age ranged from 3 to 90 years. Nine were male and 7 female patients. Onset in early infancy was characterized by erythema of the palms and sole, followed by a diffuse yellowish hyperkeratosis. Thickness of the dorsal aspect of the fingers started in childhood. Extension of hyperkeratosis to the dorsa of the hand were reported only in adults and usually precede the involvement of the feet Palmoplanatar hyperhidrosis with fetid odor between the toes was frequently seen as well as conical distal phalanges. In some adults, keratoderma gave contracture of the fingers leading to limitation of movementsMal de Meleda must be differentiated from other recessive plamoplantar keratodermas such as Papillon le fever syndrome and male de Naxos the remaining inherited pal moplantar keratodermas being autosomal dominant. Mal de meleda is rare disease but is still relatively frequent in some Tunisian regions, due to the high rare of consanguinity Mal de Meleda remains an afflicting and disabling disease
Subject(s)
Humans , Male , Female , Keratoderma, Palmoplantar/epidemiology , Antigens, Ly , Rare Diseases , Keratoderma, Palmoplantar/geneticsABSTRACT
Los autores comunican el estado actual de la endemia hidroarsenical en la Provincia de Tucumán, que compromete a los habitantes de una vasta franja territorial al este del Río Salí, donde se bebe agua de pozo de la primer napa. Describen las lesiones que la enfermedad produce en el tegumento y en órganos internos y finalmente hacen referencia al tratamiento y los casos registrados hasta el 31 de julio de 1996 en la Cátedra de Dermatología de la Facultad de Medicina de la Universidad local.